There are four separate pathways that occur in the body that can lead to small blood vessel damage due to hyperglycemia in diabetes.
Advanced glycation endproducts (AGE)
Protein kinase C (PKC)
Hexosamine pathway activation
Polyol pathway activation
Benfotiamine appears to block three of these pathways in clinical studies.An article, which appeared in the journal Nature Medicine in February 2003, titled "Benfotiamine Blocks Three Major Pathways of Hyperglycemic Damage and Prevents Experimental Diabetic Retinopathy" showed that benfotiamine did prevent diabetic retinopathy in laboratory animals.
What Benfotiamine Does:
Studies have shown that benfotiamine seems to help prevent complications of neuropathy, retinopathy and nephropathy by inhibiting the build-up of glucose in the vessels. This means that the occurrence of diabetic complications can be slowed or prevented through the application of this product.
A clinical study that appeared in the ADA journal Diabetes in 2003 showed that high-dose thiamine and benfotiamine seemed to prevent microalbuminuria and proteinuria (protein in urine) in diabetic rats. Studies done on people have shown that benfotiamine appears to also relieve diabetic neuropathic pain.
For the latest on clinical trial results for Benfotiamine...
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BENEFITS:
• Benfotiamine is a Registered Safe and Effective Product
• Benfotiaminetestimonials indicate it is effective in providing PAIN RELIEF for a myriad of painful neuropathy conditions
• Benfotiamine, medication is provided as “over the counter” non-prescription relief
• Benfotiamine doesn’t make any claim that has not been tried and proven effective by a multitude of users to date
• Benfotiamine, will not upset the stomach
• Benfotiamine FAST results, takes effect 5 to 10 minutes after application
• Benfotiamine has No alcohol, fillers or chemical additive in capsule contents
• Benfotiamine has No known side effects
• Benfotiamine contains no animal products
Pain is a universal experience. The degree to which anyone feels diabetic neuropathy pain and how they react to it, however, are the results of their own biological, psychological and cultural makeup. Past encounters with painful injury or illness also can influence an individual's sensitivity to pain and to most medications.
Proper Use of Benfotiamine
Benfotiamine should be used with caution in patients receiving class-1 anti-arrhythmic drugs such as tocainide or Mexiletine, even though peak blood levels (with three patches) will only reach one-tenth of therapeutic arrhythmia concentrations. Caution also needs to be used when using this product with patients with severe hepatic disease. Problems with skin irritation appear to be relatively mild and infrequent, and systemic side effects also appear to be relatively rare and mild because of the low levels of systemic absorption.
Dosage
Follow the directions on the label. Do not change it unless your doctor tells you to do so.


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